This process is primarily carried out by the liver
Although initially activated to buffer metabolic stress, the PINK1-Parkin pathway becomes suppressed under chronic overload, such as prolonged palmitate exposure, resulting in dysfunctional mitochondria, heightened oxidative stress, and activation of the NLRP3 inflammasome
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This is precisely why adhering to strict handling and storage protocols from the very beginning is not just best practiceit's the only practice for serious researchers
